Seven-time champion Williams had been bidding to claim a record-equalling 24th Grand Slam crown but made too many errors as Kerber ran out a comfortable winner in the final.
Earlier, compatriots Yuki Bhambri and Somdev Devvarman had also crashed out of the premier grass-court championship.
The 32-year-old, five-times a winner of the singles at the prestigious Wimbledon warm-up event, delighted a large evening centre court crowd with some fluent shot-making as he and Spanish veteran Lopez beat top seeds Juan Sebastian Cabal and Robert Farah 7-6(5), 6-3.
Images from the women's singles quarter-finals at Wimbledon on Tuesday.
India's Rohan Bopanna and Florin Mergea battled past Thomas Bellucci and Guillermo Duran in straight sets to progress to the pre-quarterfinals of the Wimbledon men's doubles event, in London on Friday.
On court Novak Djokovic is taking tennis to extraordinary new levels with his single-minded obsession with winning; off it the Serbian is more than happy to share power. The 29-year-old will begin his attempt to win a fourth Wimbledon title on Monday when he plays British wildcard James Ward on Centre Court -- 12 months after claiming a second successive title by beating Roger Federer.
The Czech Republic won a heavyweight clash against the United States with a deciding doubles victory sending them through to the Billie Jean King Cup semi-finals in Seville.
Wimbledon debutant Eubanks ends Tsitsipas's challenge in fourth round.
Rohan Bopanna and his Australian partner Matthew Ebden advanced to the second round with a straight-set win over Christopher O'Connell and Aleksandar Vukic.
Mahesh Bhupathi, Rohan Bopanna and Sania Mirza advanced to the second round of doubles events at Wimbledon on Wednesday.
India's Sania Mirza crashed out of the mixed doubles competition while Rohan Bopanna and his partner entered the quarter-finals of the Wimbledon Championships.
The 27-year-old beat fourth seed Frank Dancevic of Canada to qualify for the grass court Grand Slam.
Brazil's Marcelo Melo and Andre Sa set a new men's doubles record at Wimbledon in terms of games played and most games played in the deciding set.
Mahak Jain suffered a tame defeat to crash out of girls singles event of the junior Wimbledon championship while Zeel Desai got lucky as she lost the first set but still advanced to the pre-quarterfinals after her opponent retired mid-way into the contest, in London, on Monday.
Indian doubles pair of Yuki Bhambri and Saketh Myneni put up a valiant fight before going down to Alejandro Davidovich Fokina of Spain and Adrian Mannarino of France in a three-setter.
Indian tennis stalwarts Leander Paes and Mahesh Bhupathi, who were locked in a selection row for the London Olympics recently, saw their fortunes take different turns with the former reaching the third round of the men's doubles event while the latter crashed out of mixed doubles competition of the Wimbledon.
India's Sania Mirza and Switzerland's Martina Hingis entered the women's doubles third round.
PHOTOS from day two of the Wimbledon championships at the All England Lawn Tennis and Croquet Club in London on Tuesday.
The 33-year-old Aussie won a record ninth Wimbledon title when he and Jonas Bjorkman beat Julian Knowle and Nenad Zimonjic.
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IMAGES from Day 6 at Wimbledon on Saturday.
Capping off a great day for India, Sania Mirza advanced to the third round of both the women's and mixed doubles events, while Rohan Bopanna and Purav Raja also won their respective mixed doubles matches at the Wimbledon in London.
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The 23-year old confirmed she was still suffering with a throat infection which forced her out of the women's doubles.
The Czech Republic was enjoying a hat-trick of Wimbledon triumphs on Sunday when Iveta Benesova teamed up with Austrian Juergen Melzer to capture the mixed doubles title with a 6-3, 6-2 win over Mahesh Bhupathi and Elena Vesnina.
The Murray bothers last played together at the 2016 Rio Olympics, and were a prolific partnership when Britain won the Davis Cup in 2015.
The 42-year-old Paes now has won nine Grand Slam mixed doubles titles, surpassing compatriot and former partner Mahesh Bhupathi's record of eight titles.
Leander Paes and Radek Stepanek of Czech Republic entered the semifinals in men's doubles while another Indian Sania Mirza and her Romanian partner Horia Tecau lost 5-7, 3-6 to the 10th-seeded British-Australian pair of Jamie Murray and Casey Dellacqua in the mixed doubles pre-quarters at the Wimbledon Championships in London on Thursday.
Images from the Wimbledon matches played on Monday.
The odds of the Federer twins winning a Wimbledon doubles title in the future have dramatically shortened after Roger Federer and his wife Mirka announced the birth of a second set of twins on Tuesday.
Tennis great Vijay Amritraj says there should be least controversy with regards to India's doubles combination in Davis Cup since the doubles match matters only when there are 'even singles matches'.
IMAGES from the French Open quarter-finals played in Paris on Tuesday.
Nicolas Mahut and Pierre-Hughes Herbert became the third home duo to win the French Open men's doubles when they beat second seeds Oliver Marach and Mate Pavic 6-2, 7-6(4) on Saturday.
The second round of this year's Wimbledon has equalled the record for withdrawals and retirements for a single round at a Grand Slam in the professional era after two more players quit on Thursday.
It would be hard to bet against the Williams sisters meeting in their first Wimbledon final since 2009, but Angelique Kerber and Elena Vesnina won't just be making up the numbers in the last four on Thursday. While unseeded Vesnina has described her semi-final against world number one Serena Williams as a dream, she is playing inspired tennis, bringing the guile from two doubles slams to deliver baseline power and a deft touch at the net.
Storm Hunter and Elise Mertens picked up the Doubles Team of the Year award, China's Zheng Qinwen was named Most Improved Player while Russian Mirra Andreeva won Newcomer of the Year.
Roger Federer began his 63rd consecutive Grand Slam tournament with a majestic 6-1, 6-3, 6-3 first-round win over little-known Bosnian Damir Dzumhur at Wimbledon in London, on Tuesday.
The seventh-seeded Indian combination got the better of Marcel Felder of Uruguay and Tunisia's Malek Jaziri 6-0, 7-6 (1), 6-2 in their first round match.
Andy Murray once again fills the prime time viewing slot on Centre Court late on Saturday, while five-time women's champion Venus Williams will have revenge on her mind against Carla Suarez Navarro.
